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TEST NAME: Paraneoplastic AutoAntibody Evaluation, Spinal Fluid **

CPT CODE: 81596, 83107, 83108, 83185, 83378, 89381
NGMC CODE: PAES
SPECIMEN REQUIREMENTS: 4 mL serum. Refrigerated.
DEPT/TURNAROUND: Send Out/3-5 days
METHODOLOGY: ANN1C, ANN2C, ANN3C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, AGN1C, NMDIC, AMPIC, GABIC: Indirect Immunofluorescence Assay (IFA)
WBNC, CRMWC, ABLTC: Western Blot
GD65C, VGKCC: Radioimmunoassay
NMOCC, NMDCC, AMPCC, GABCC: Cell-Binding Assay (CBA)
REFERENCE RANGES:

Profile Information

Test ID Reporting Name Available Separately Always Performed
ANN1C Anti-Neuronal Nuclear Ab, Type 1 No Yes
ANN2C Anti-Neuronal Nuclear Ab, Type 2 No Yes
ANN3C Anti-Neuronal Nuclear Ab, Type 3 No Yes
AGN1C Anti-Glial Nuclear Ab, Type 1 No Yes
PcA1C Purkinje Cell Cytoplasmic Ab Type 1 No Yes
PCA2C Purkinje Cell Cytoplasmic AB Type 2 No  Yes
PCTRC Purkinje Cell Cytoplasmic AB Type Tr No Yes
AMPHC Amphiphysin Ab, CSF No Yes
CRMC CRMP 5-IgG, CSF No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
WBNC Paraneoplas Autoantibody WBlot, CSF No No
CRMWC CRMP-5-IgG Western Blot, CSF No No
GD65C GAD65 Ab Assay, CSF Yes No
ABLTC Amphiphysin Western Blot, CSF No No
NMOCC NMO/AQP4-IgG CBA, CSF Yes No
NMDCC NMDA-R Ab CBA, CSF No No
AMPCC AMPA-R Ab CBA, CSF No No
GABCC GABA-B0R Ab CBA, CSF No No
NMDIC NMDA-R Ab IF Titer Assay, CSF No No
AMPIC AMPA-R Ab IF Titer Assay, CSF No No
GABIC GABA-B0R Ab IF Titer Assay, CSF No No
VGKCC VGKC-complex Ab IPA, CSF No No


Testing Algorithm

If indirect immunofluorescence assay (IFA) (ANN1C, ANN2C, ANN3C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, AGN1C) is indeterminate, then paraneoplastic autoantibody Western blot is performed at an additional charge.

If IFA pattern suggest NMO/AQP4-IgG, then NMO/AQP4-IgG CBA is performed at an additional charge.

If client requests, or if IFA patterns suggest CRMP-5-IgG, then CRMP-5-IgG Western blot is performed at an additional charge.

If IFA patterns suggest GAD65 antibody, then GAD65 antibody radioimmunoassay is performed at an additional charge.

If IFA patterns suggest neuronal voltage-gated potassium channel-complex autoantibody, then VGKC-complex antibody IPA is performed at an additional charge.

If IFA patterns suggest amphiphysin antibody, then amphiphysin Western blot is performed at an additional charge.

If IFA pattern suggest NMDA-R, then NMDA-R antibody CBA and/or NMDA-R titer is performed at an additional charge.

If IFA pattern suggest AMPA-R, then AMPA-R antibody CBA and/or AMPA-R titer is performed at an additional charge.

If IFA pattern suggest GABA-B-R, then GABA-B-R antibody CBA and/or GABA-B-R titer is performed at an additional charge.



In patients with a history of tobacco use or other lung cancer risk, or if thymoma is suspected, PAVAL / Paraneoplastic Autoantibody Evaluation, Serum is also recommended

                                                                                                                                            


 

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