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TEST NAME: Antineutrophil Cytoplasmic Autoantibodies (ANCA), with Reflex to Titer and MPO/PR3 Antibodies

CPT CODE: 86255 ANCA; if reflexed, add 86256 ANCA titer and 83516 x2 MPO/PR3 Antibodies
NGMC CODE: ANCARF
SPECIMEN REQUIREMENTS: 2 mL serum.  Separate serum from cells ASAP. Refrigerate.
DEPT/TURNAROUND: Send Out/3-6 days
METHODOLOGY: Indirect Fluorescent Antibody/Multi-Analyte Fluorescent Detection
REFERENCE RANGES:
 
Components Reference Interval
Anti-Neutrophil Cytoplasmic Antibody, IgG < 1:20: Not significant
Myeloperoxidase Antibody:

Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater
Serine Protease 3 Antibody :

Negative: 19 AU/mL or less
Equivocal: 20-25 AU/mL
Positive: 26 AU/mL or greater

Note:
Myeloperoxidase Antibody and Serine Protease Antibody are performed only if the ANCA IgG screen reveals a titer of 1:20 or greater.

Interpretive Data:
Neutrophil Cytoplasmic Antibodies (C-ANCA = granular cytoplasmic staining, P-ANCA = perinuclear staining) are found in the serum of over 90% of patients with certain necrotizing systemic vasculitides, and usually in less than 5% of patients with collagen vascular disease or arthritis. Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO.  Approximately 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.


 

 

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